CLINICAL PRO PDRN ADVANCED CREAM

Advanced anti-wrinkle, regenerating and radiance cream formulated with an exceptionally high concentration of Salmon PDRN, one of the highest available in professional daily-use skincare.

• A high-performance, Collagen-supporting cream that helps reduce the visible appearance of wrinkles, fine lines, and expression lines, while restoring skin vitality, brightness and smoothness.

• Enriched with Salmon PDRN, Centella Exosomes, Multi-Peptides, and Ceramides, it helps improve elasticity, firmness, and overall skin radiance.

• The refined cream-gel texture delivers lasting hydration and nourishment with a light, fast-absorbing feel.

• Leaves the skin feeling supple, refreshed, and comforted, with a visibly smoother, more luminous appearance.

 Clinically evaluated to help:

• Reduce the appearance of wrinkles and expression lines

• Improve firmness, elasticity, and skin density

• Strengthen the skin barrier and improve resilience

• Enhance radiance and evenness of skin tone

• Provide long-lasting hydration and comfort

Clinically Proven Results at 28 days

28-day use and instrumental study under dermatological control, 22 volunteers 

• Anti-Wrinkle effect: +21% Skin Surface Smoothing & −6% Visible Number of Wrinkles

• +16% Collagen support - Skin Density

• +6% Elasticity & +6% Firmness

• −7% TEWL / Barrier Reinforcement

• 100% reported improved radiance, hydration, smoothness & overall skin appearance

Suitable for all skin types, including sensitive skin.
97% Natural Origin Ingredients (ISO 16128)

Dermatologically tested on sensitive skins

Use

Lightweight hydrogel cream for superior comfort, long-lasting hydration with a fresh, non-greasy, fast-absorbing finish.

Daily anti-aging and revitalizing care.
Pre & Post-procedure care, in-clinic or at home.
Apply morning and evening to clean, dry skin (face and neck). Massage until absorbed. Can be used alone or after CLINICAL PRO PDRN & EXOSOMES BIO SERUM for enhanced results.

Suitable for all skin types, including sensitive skin.

97% Natural Origin Ingredients (ISO 16128)

Dermatologically tested on sensitive skins

Details

Clinically Tested Performance

28-day use and instrumental study under dermatological control, 22 volunteers

· Collagen Support – Skin Density

+16% increase in skin density

Ultrasound measurements using Dub® SkinScanner 75.

· Anti-Wrinkle Effect

−6% reduction in visible number of wrinkles

Wrinkle measurements performed using PRIMOS® CR.

+21% improvement in skin surface smoothing effect

Skin surface volume measurements using Visioscan® VC 20plus.

· Epidermal Barrier Support

−7% reduction in transepidermal water loss (TEWL)

100% of volunteers showed a measurable reduction in TEWL.

TEWL measurements using Tewameter® TM 300.

· Hydration

100% of volunteers showed improved skin hydration.

Hydration measurements using Corneometer®.

· Elasticity & Firmness

+6% increase in elasticity

+6% increase in firmness

Improvement observed in 100% of volunteers.

Measurements performed using Cutometer®.

Self-Assessment Results

• 100% reported improved hydration, long-lasting moisturization and reduced feeling of dryness

• 100% reported enhanced radiance, fresher-looking skin and improved overall skin appearance

• 95% reported improved appearance of uneven skin tone

• 86% reported a more even-looking complexion, with improved appearance of dark spots and sun discoloration

• 100% reported improved appearance of skin regeneration and visible wrinkle / expression-line appearance

• 100% reported improved firmness, elasticity and skin density / plumpness

• 100% reported smoother, softer skin

FORMULATION HIGHLIGHTS & ACTIVE COMPLEXES

> Skin Renewal & Rejuvenation Complex

• PDRN (100% Salmon Polynucleotides) - 2000ppm (0.2%): Highly purified DNA fragments extracted from Salmon DNA that help support cellular metabolism, promote revitalization, and improve skin elasticity and texture. Known for their ability to help stimulate
fibroblast activity and optimize the skin’s natural regeneration processes, PDRN molecules contribute to smoother, firmer, and more luminous skin.

Phyto - Exosomes & Stem Cells (Centella & Red Grape) :Plant derived growth factors and phytonutrients to boost skin renewal and resilience, helping improve elasticity and reduce visible signs of stress.

> Collagen Support & Firmness Complex

• Adenosine + Silanol: Adenosine is an active molecule known in dermatology for its contribution to improving the appearance of wrinkles and epidermal smoothness. In combination with Silanols, it supports the natural skin regeneration process and contributes to a more elastic, uniform and youthful appearance of the skin.

• Hydroxyproline + Silanol: Vegan Hydroxyproline (Collagen Fragment) with Silanols to support a plumper, firmer-looking skin surface.

• Poly-Peptide Complex

• Acetyl Hexapeptide-8: Helps reduce the appearance of expression lines by relaxing micro-tension (“Botox-like effect”).

• Palmitoyl Tripeptide-38: Advanced Peptide that supports the natural synthesis of Collagen (types I, III and IV), Fibronectin, Hyaluronic Acid and Laminin-5, helping to improve the appearance of wrinkles and skin elasticity ('Retinol-like' effect).

• Acetyl Tetrapeptide-2: Innovative biomimetic peptide that helps reinforce dermal cohesion and elasticity by stimulating key structural proteins such as Elastin and Fibrillin, promoting a lifted and more defined facial contour.

• Copper Tripeptide: Antioxidant peptide complex that supports natural Collagen and Elastin production, helping improve

> Brightening, Antioxidant & Tone-Perfecting Complex

• Niacinamide + Tranexamic Acid: Work synergistically to help reduce the appearance of uneven pigmentation, dullness, and dark spots. Contribute to a clearer, brighter, and more uniform complexion while supporting the skin’s barrier function.

• Resveratrol: Grape-derived polyphenolic antioxidant that helps defend against oxidative stress and photoaging. Supports Collagen integrity, skin vitality, and a more radiant, resilient complexion.

• Pomegranate Extract (Punicalagins, Polyphenols, Ellagic Acid): Provide antioxidant protection and enhance skin luminosity.

• Coenzyme Q10 + Carnitine in Liposomes: Energy-restoring antioxidant complex that protects against oxidative damage and supports cellular metabolism. Enhances firmness, elasticity, and overall skin radiance.

> Skin Barrier & Hydration Complex

• Ceramide NG + Ethyl Linoleate + Shea Butter + Squalane (Olive) + Chia Oil (Omega-3 &-6 fatty acids) : Help reinforce the skin barrier, reduce transepidermal water loss, and improve comfort during retinoid use.

• Beta-Glucans + Panthenol + Allantoin + a-Bisabolol: Help soothe the skin and reduce sensations of dryness or irritation commonly associated with retinoid use.

• Multi-Weight Hyaluronic Acid (1,5 MDa, 350KDa, 40KDa) + Biosaccharide Gum-1 + Trehalose + Betaine: Reinforce and maintain the skin’s hydration levels, improving suppleness and comfort.